The Center for Genome Engineering (CGE) at the Institute for Basic Science (IBS) focuses on developing unique, advanced technologies for genetic modification, including but not limited to genome editing tools (Cas proteins and zinc finger nucleases), conditional knock-out and knock-in cassette designs, and mosaic genetics.
We use AI-based structure prediction strategies to design genome editors that have increased efficiency and lowered immunogenicity compared to earlier versions. These pioneering tools are applied among an expanded spectrum of model species (humans, rodents, non-rodent mammals, fish, and plants) in the forms of cell lines to organoids and full-system organisms. We aim to acquire a sophisticated level of genetic modification and regulation in both single-cell and organismal resolutions.
The CGE is globally known for its high-end core facilities for genetic mouse engineering, stem cell cultures, sequencing, and histologic preparations. Cores for single-cell and spatial genomics, high-content screening, fish breeding, and plant growth have been added to support the growing scale of both individual and collaborative research at the center.
