IBS Institute for Basic Science
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Programmable nucleases for genome editing
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Programmable nucleases for genome editing
Gene and cell therapy
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Gene and cell therapy
Plant biology and crop research
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Plant biology and crop research
Cell reprogramming and animal reproduction
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Cell reprogramming and animal reproduction

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Introduction

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  • We focus on developing programmable nucleases that enable genome editing in plants, animals, and cultured cells including human pluripotent stem cells. These nucleases cleave chromosomal DNA in a targeted manner, producing DNA double-strand breaks (DSBs), whose repair via endogenous mechanisms gives rise to targeted genome modification in cells and whole organisms.
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