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Introduction

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• We focus on developing programmable nucleases that enable genome editing in plants, animals, and cultured cells including human pluripotent stem cells. These nucleases cleave chromosomal DNA in a targeted manner, producing DNA double-strand breaks (DSBs), whose repair via endogenous mechanisms gives rise to targeted genome modification in cells and whole organisms.

Publications

• Choongil Lee;Dong Hyun Jo;Gue-Ho ...

  CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors MOLECULAR THERAPY 27, 8 2019

• Beomsue Kim;Masahiro Fukuda;Jung-...

  Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58, 24 2019

• Marion Gruffaz;Hongfeng Yuan;Wen ...

  CRISPR-Cas9 Screening of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Cells Identifies XPO1 as a Vulnerable Target of...

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