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Introduction

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• We focus on developing programmable nucleases that enable genome editing in plants, animals, and cultured cells including human pluripotent stem cells. These nucleases cleave chromosomal DNA in a targeted manner, producing DNA double-strand breaks (DSBs), whose repair via endogenous mechanisms gives rise to targeted genome modification in cells and whole organisms.

Publications

• Do-Hun Kim; Chul-Yong Park; Sung-...

  Generation of a human induced pluripotent stem cell line, YCMi002-A, from a Factor VII deficiency patient carrying F7 mutations ...

• Yoon, A.-R.; Jung, B.-K.; Choi, E...

  CRISPR-Cas12a with an oAd Induces Precise and Cancer-Specific Genomic Reprogramming of EGFR and Efficient Tumor Regression MOLEC...

• Amy L. McGuire; Stacey Gabriel; S...

  The road ahead in genetics and genomics NATURE REVIEWS GENETICS 21, 10 2020

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